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They are sensitive to medications, and adverse effects are common.

Antidepressants are the third most-prescribed drugs in the United States.

Certain anticonvulsants and antidepressants clearly decrease pain sensitivity.

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While a 120 mg/day dose was shown to be effective, there is no evidence that doses greater than 60 mg/day confer any additional benefits.

Do not take two doses of Cymbalta at the same time.Selective serotonin reuptake inhibitors (SSRIs) are the drug of choice for treatment of patients with panic disorder.Most patients have a favorable response to SSRI therapy; however, 30 percent will not be able to tolerate these drugs or will have an unfavorable or incomplete response.Administer Cymbalta at a total dose of 40 mg/day (given as 20 mg twice daily) to 60 mg/day (given either once daily or as 30 mg twice daily).For some patients, it may be desirable to start at 30 mg once daily for 1 week, to allow patients to adjust to the medication before increasing to 60 mg once daily.

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